This blog post will be an archive for various data points and expert opinions on drugs not commonly used or in clinical trials for DMGs. Parents consider these based on hypothesized effects or pre-clinical data.
Salinomycin People have published that Salinomycin targets cancer stem cells there are invitro studies on its use in GBM cells. Salinomycin (Sali) is an anticoccidial polyether antibiotic. 20240329 (pre clinical DIPG experts) The drug seems to be toxic and does not cross the BBB https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258498/
TIL Therapy 20240329 (pre clinical DIPG experts) DMGs are pretty immunologically cold / quite but I wonder if we should try such for a complicated cancer such as DMG
Disulfram 20240330 (pre clinical DIPG experts) Disulfram alone is not effective in DMGs. In combination with ONC is only additive. The additive score of Disulfram and ONC is not too high.
VENCLEXTA® (venetoclax tablets) 2023 pre clinical data showed good results. But BBB penetration levels are to too low for any theraputic levels. Venclexta and Venclyxto, is a medication used to treat adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia.
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